Atherosclerosis and Rheumatic Diseases

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Atherosclerosis and Rheumatic Diseases

Until recently, patients with chronic autoimmune diseases were dying at a young age from their disease. However, with the emergence of biologic drugs and disease-targeted therapies, longevity in this patient population has increased. In addition, physicians have become more aware of the long-term sequelae of chronic inflammation focusing mainly on the development of premature atherosclerosis. I...

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Leader Inflammation-mediated rheumatic diseases and atherosclerosis

For over 20 years, premature coronary heart disease has been recognised as a major determinant of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Less appreciated is the fact that the same holds true for patients with rheumatoid arthritis (RA). These two autoimmune diseases share a propensity to target women of childbearing age and a treatment armamentarium that inc...

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Leader Inflammation-mediated rheumatic diseases and atherosclerosis

For over 20 years, premature coronary heart disease has been recognised as a major determinant of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Less appreciated is the fact that the same holds true for patients with rheumatoid arthritis (RA). These two autoimmune diseases share a propensity to target women of childbearing age and a treatment armamentarium that inc...

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Accelerated atherosclerosis in autoimmune rheumatic diseases.

Atherosclerosis is a multifactorial process that commences in childhood but manifests clinically later in life. Atherosclerosis is increasingly considered an immune system–mediated process of the vascular system. The presence of macrophages and activated lymphocytes within atherosclerotic plaques supports the concept of atherosclerosis as an immune system–mediated inflammatory disorder.1,2 Infl...

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ژورنال

عنوان ژورنال: Rheumatology: Current Research

سال: 2015

ISSN: 2161-1149

DOI: 10.4172/2161-1149.1000147